Tissue biorepositories provide a resource that can be utilized to be utilized to investigate cancer pathology, genetics and biomarkers . The pediatric tumor/tissue biorepository will serve as a valuable resource for collaborative studies aiming to understand links between tumor biology and clinical behavior and response to therapy. These specimens can also be used to evaluate prognostic biological markers in relation to serial clinical interventions.
Patients 0-21 years of age, who are newly diagnosed with primary or recurrent tumors
Tissue from the tumor will be obtained at the time of diagnostic or therapeutic surgery- no extra procedure would be done solely for research use. In parallel, we are also collecting 2-5 mL of peripheral blood, during blood drawing for diagnostic purposes.
Collected samples will be proccessed to include: a) Fresh frozen tissues, b) Paraffin embedded tissues, c) Extreacted RNA, d)Extracted DNA and e) Serum & Plasma (initial and follow up)
Patients 0-21 years
of age, who are newly diagnosed with primary or recurrent tumors, will be
eligible. Patients older than 21 years
of age will be eligible if they have pediatric-type tumors (medulloblastoma,
Patients older than 21 yeras of age, who do not have pediatric- type tumors
Healthy subjects