Clinical Research Details

Descriptive Information
The Acute Vascular Effects of Waterpipe Smoking

Hassan Chami



Conditions and Keywords
Evaluate the acute effects of water pipe smoking on arterial stiffness as well as endothelial and pulmonary functions.
Arterial Stiffness,Acute smoking,endothelial function,Impulse Oscillometry
Study Design
Case Control
Eligibility and IRB
Min: 18
Max: 30

We hypothesize that WPS is associated with increased risk of vascular impairment. Tonometry and digital thermal monitoring (DTM) are non-invasive tests used to assess arterial stiffness and vascular function respectively. Impulse oscillometry (IOS) is used to assess pulmonary resilience/reactance. We proposed to conduct an experimental study on 60 waterpipe smokers (30 daily and 30 occasional) and 30 non-smokers from the young community (age 18-30 years old) in Beirut. Participants will be invited to AUBMC where WPS will be assessed using a standardized questionnaire. Height, weight, heart rate, blood pressure, tonometry, DTM, IOS and exhaled CO will be measured. Waterpipe smokers will be asked to smoke a waterpipe for 30 minutes in a nearby café using a “smart mabsam” to record their number of puffs and duration while never smokers will be invited to sit in the same environment with the smoker to evaluate the effect of second hand exposure to WPS for the same duration. Blood pressure, tonometry, DTM, IOS and exhaled CO will be reassessed after this session for all participants at AUBMC. Comparisons between before and after waterpipe exposure for all assessed measures will be done among each group. Analysis will also include comparisons between the three groups using their baseline measures.

 This study includes 90 healthy young adults aging between18 and 30 years old from Beirut split equally into three different groups who differ in their waterpipe smoking patterns: 30 never smokers (waterpipe/ cigarette/ cigar), 30 occasional waterpipe smokers (excluding cigarette and cigar smokers), 30 daily waterpipe smokers (excluding cigarette and cigar smokers) who have been smoking for more than a year.


Healthy young adults aging between 18 and 30 years old and are either exclusive waterpipe smokers (daily or occasional) and have been smoking for more than a year or never smokers (waterpipe/ cigarette/ cigar) will be included in the study.

Cigarette and cigar smokers, patients with history of asthma, diabetes, renal failure, atherosclerosis and underlying hypertension or cardiovascular disease (coronary heart disease, myocardial infarction, revascularization procedures, congestive heart failure, peripheral and cerebrovascular vascular disease), coronary artery disease, Hematological disease such as thrombocytosis and malignancy will be excluded. Pregnant women will not be invited to take part of this study since it includes exposure to smoking that might be harmful for the fetus.