Clinical Research Details

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Descriptive Information
Immunological Pattern During Multiple Sclerosis Relapses and Response to Treatment

Samia Khoury
sk88@aub.edu.lb

IM.SK1.02
Recruiting

Clinical Research - Mechanisms of Human Disease  


No
Collaborators
  • Hala Darwish
  • Bassem Yamout
  • Samir Atweh
  • Raja Sawaya
Coordinators
Cynthia Eid
ce32@aub.edu.lb
Extension: 7436
Conditions and Keywords
Multiple Sclerosis
Multiple Sclerosis
Study Design
Other: Describe in Detailed Description
To establish a link between immune abnormalities in the peripheral blood of MS patients during relapses and the level of disease activity as measured clinically and by MRI imaging. To establish a link between the MS patients’ immune responses to currently used drugs for MS.
N/A: Not Applicable
Prospective
N/A: Not Applicable
N/A: Not Applicable
N/A: Not Applicable
Cohort
Eligibility and IRB
Both
Min: 7
Max:
Yes
No
The aims of the study are to establish a link between immune abnormalities in the peripheral blood of MS patients and the level of disease activity as measured clinically and to establish a link between immune measures during an MS attack and before and after initiation of treatment.
The study is prospective and consists of establishing a bank of serum, plasma, and cells, to develop disease biomarkers and follow the course of the disease and response to treatment. Subjects will be recruited from patients at the MS center of AUBMC. Blood will be obtained before start of therapy, and at 3, 6, and 12 months after start of a new therapy. For patients in relapse blood will be obtained at the time of visit or before the start of intravenous steroids and at the 3-month follow-up
Multiple Sclerosis patients visiting the MS Center

Non-probability

Patients diagnosed with MS following the revised McDonald MS diagnostic criteria, patients with clinically isolated syndrome, and patients with neuromyelitis optica will be included.

Patients with neurological diseases not within the MS spectrum
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