Details - Clinical Research

Clinical Research Details

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Descriptive Information

Title

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers

Investigator Name

Raya Saab

rs88@aub.edu.lb

Protocol Id

NMTRC 009

Status

Recruiting

Study Type

Clinical Research - Clinical Trials (phase 0, 1,2 3 & 4)

Phase

Phase 2

Looking for Med Students Volunteers

Collaborators

NMTRC (Neuroblastoma and Medulloblastoma Translational Research Consortium)

Sponsors

NMTRC (Neuroblastoma and Medulloblastoma Translational Research Consortium)

Conditions and Keywords

Conditions

Refractory solid tumors, pediatrics

Keywords

genomics, personalized medicine

Study Design

Primary Purpose

Treatment

Classification

Safety and/or Efficacy Study

Time Perspective

Prospective

Masking

Open Label

Intervention Model

Single Group

Allocation

N/A: Single arm study

Observational Study Model

N/A: Not Applicable

Eligibility and IRB

Gender

Both

Age Limits

Min: 0

Max: 18

IRB Approval

Yes

Healthy Volunteer

Study Description

The primary objective of this study is to determine feasibility of using tumor samples to assess genomic mRNA expression arrays and DNA Mutation Panels using predictive modeling to make real-time treatment decisions for children with relapsed/refractory cancers. Secondary objectives include assessment of response, and evaluation of safety of the decision-making process, exploring the relationship between tumor genotype/phenotype and response.

Population Description

Pediatric Oncology patients with resistant solid tumors

Sampling Method

Inclusion Criteria

Exclusion Criteria

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