Background: Vitamin D acts as a neurosteroid that crosses the blood brain barrier and exerts its function on a number of receptors. Absence of vitamin D during brain development is associated with altered dopamine metabolism and reduced neurotransmitter turnover. During pregnancy low maternal vitamin D levels have been associated with cognitive impairment of their offspring, however this correlation remains controversial.
Aim: To assess the neurodevelopmental outcome of children born to
mothers who received two different doses of vitamin D during pregnancy
Methods: This is a cohort study taking place at three different university centers in Beirut from 2017 to 2020. Infants of mothers participating to the “Vitamin D supplementation in pregnancy” trial and whose parents provide written informed consent will be enrolled. Demographic and neonatal information will be retrieved from medical records at birth and before discharge. Infants will be assessed again at 18 months and 3 years for their neurodevelopment using the Bayley Scale for Infant Development (BSID-III).
Infants of mothers participating to the “Vitamin D supplementation in pregnancy” trial and whose parents provide written informed consent will be enrolled.