Clinical Research Details

Descriptive Information
A chart-based association study of newer antidepressant medication use and weight change in a population in Lebanon

Joseph R El-Khoury


Clinical Research - Epidemiologic and Behavioral Studies  

  • Paul Noufi
  • Antoine Beano
Ghaidaa Majari
Conditions and Keywords
Anxiety disorder,Major Depressive Disorder,MDD
Major Depressive Disorder,Anxiety Disorder,MDD,Antidepressant,SSRI,SNRI,Weight,Weight change,Weight gain
Study Design
Other: Describe in Detailed Description
Retrospective longitudinal study to describe the six months evolution of weight in adult patients recently initiated on the most commonly used antidepressants
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Eligibility and IRB
Min: 18

The main purpose of the study is to describe the association between antidepressant treatment and weight change in the Lebanese population over a 6 month follow up period. The results of the paper will shed light on weight change patterns across the most commonly prescribed antidepressants and will allow comparison to findings in other populations. It will also help clinicians in Lebanon and other Arab Middle-Eastern countries to make evidence-based choice of antidepressants while taking into consideration specific patient profile.

The study population will include adult patients (above 18 years of age) started on outpatient basis on second-generation antidepressants for any psychiatric illness and maintained on treatment for at least 1 month. 

Sample of charts will be collected from the adult psychiatry outpatient clinics at AUBMC that includes 3 practitioners with their prior permission.

  1. Adult patients (above 18 years of age).
  2. Started on outpatient basis on second-generation antidepressants for any psychiatric illness.
  3. Treatment maintained for at least 1 month. 

  1. Presence of co-morbid eating disorders.
  2. History of bariatric surgery.
  3. Patients on other psychotropic medication, except for Benzodiazepines or sleeping aids (to include Z-Drugs, Melatonin, Atarax etc.).
  4. Patients with thyroid problems 
  5. Patients on meformin