Clinical Research Details

Descriptive Information
A Global Registry on Mucormycosis By The ECMM/ISHAM Working Group on Zygomycosis

Souha Kanj Shararah



  • ECMM/ISHAM Working Group on Zygomycosis
Jeff Jabbour
Saeed El Zein
Extension: 2093
Conditions and Keywords
A global registry on mucormycosis to better understand the various aspects of this rare disease
Study Design
Other: Describe in Detailed Description
Observational, epidemiologic
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Retrospective chart review of all cases of mucormycosis diagnosed at AUBMC between 2008 and 2017
Eligibility and IRB

Although often described as a rare fungal infection, mucormycosis appears to be increasing in frequency. This has been attributed to the growth of the number of severely immunocompromised patients, as well as to the rising prevalence of diabetes mellitus. Differences in the epidemiology seem to exist depending on geography. In Europe and USA, the disease remains uncommon and is mostly seen in patients with hematological malignancies. In contrast, in Asia, especially in India, mucormycosis is more common, and cases occur mainly in patients with uncontrolled diabetes mellitus or trauma. It mainly affects immunocompromised patients, such as those with haematological malignancies, recipients of haematopoietic stem cell or solid organ transplants, patients with diabetes mellitus, and infants with prematurity. Mucormycosis may also affect immunocompetent patients with trauma or burns, or patients with elevated serum levels of iron under treatment with deferroxamine. Due to the relative rarity of the disease it is difficult to perform stringent epidemiological studies to estimate its exact incidence. Most of the available data stem from case series and pertain to haematological patients or to patients who have undergone transplantation.

Taking into consideration the challenges related to epidemiology, treatment and outcome of mucormycosis, a Working Group on Zygomycosis was formed by the European Confederation of Medical Mycology (ECMM). The aim of the group was to analyze the clinical characteristics, microbiology, treatment practices and outcome of mucormycosis in Europe through a voluntary case registry. The results of the first 3 years (2005–2007) were published in 2011. In 2008 the Working Group became global, under the auspices of both ECMM and ISHAM (Ιnternational Society for Human and Animal Mycology).

All patients diagnosed with invasive fungal infections due to agents of mucormycosis

All patients admitted to AUBMC between 2008 and 2017 and who are diagnosed with invasive fungal infection due to agents of mucormycosis. Patient's charts will be reviewed and assessed for eligibility 

Inclusion Criteria
• The patient must have an invasive fungal infection due to agents of
mucormycosis, diagnosed by direct microscopy, culture, histopathological or
DNA evidence.
• The methods of diagnosis must be clearly stated.
• The case must not be older than 2008.

Exclusion Criteria
• If the data indicate that the positive culture represents colonization, the case
is not eligible.