This is a retrospective chart review of 84
breast cancer patients at AUBMC. A previous study done by Dr. Tfayli (IM.AT.05
Gene expression profiling of breast cancer in Lebanese women) collected fresh
breast cancer pathology samples from newly diagnosed early-stage breast cancer
patients with no prior history of malignancy or chemotherapy. Microarray
analysis was performed on these samples to determine gene expression. Based on
the results, the samples were divided into the following classes: Luminal A [Estrogen
Receptor Positive (ER+); low grade], Luminal B [ER+; high grade], HER2 positive
(HER-2 amplification) and basal [ER-; Progesterone Receptor Negative (PR-);
HER-2-]. The aim of this project will be to assess the correlation between the
above-mentioned molecular subtypes and the expression of ER, PR, HER-2.