Clinical Research Details

Descriptive Information
The role of ACE, eNOS and ADRB2 genetic polymorphisms in hypertension

Nathalie Khoueiry-Zgheib
nk16@aub.edu.lb

N/A
Completed- Has Results

Observational  


No
Conditions and Keywords
Hypertension
Hypertension, genetic polymorphisms
Study Design
Basic / Translational
N/A: Not Applicable
Retrospective
N/A: Not Applicable
N/A: Not Applicable
N/A: Not Applicable
Cohort
Eligibility and IRB
Both
Min:
Max:
Yes
No

We performed 2 case-control association studies whereby we looked at the role of genetic polymorphisms in ACE, eNOS  and beta2-adrenergic receptors with risk of hypertension. We used  historic controls who  were previously recruited for a separate study (see the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation). 


Manuscript 1: Akra-Ismail M, Makki RF, Chmaisse HN, Kazma A, Zgheib NK. Association between angiotensin-converting enzyme insertion/deletion genetic polymorphism and hypertension in a sample of Lebanese patients. Genet Test Mol Biomarkers. 2010 Dec;14(6):787-92 (PMID: 20939740 ).

Manuscript 2: Soudani NY, Fakhoury RM, Kaissi SS, Zgheib NK. The role of genetic polymorphisms in endothelial nitric oxide synthase and beta2-adrenergic receptors with risk of hypertension in a sample of Lebanese people. Saudi Med J. 2014 Mar;35(3):255-60 (PMID: 24623205). 


See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.


See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.


See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.


See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.