Details - Clinical Research

Clinical Research Details

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Descriptive Information

Title

The role of ACE, eNOS and ADRB2 genetic polymorphisms in hypertension

Investigator Name

Nathalie Khoueiry-Zgheib

nk16@aub.edu.lb

Protocol Id

N/A

Status

Completed- Has Results

Study Type

Observational A clinical study in which participants identified as belonging to study groups are assessed for biomedical or health outcomes. Participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).

Phase

Looking for Med Students Volunteers

Conditions and Keywords

Conditions

Hypertension

Keywords

Hypertension, genetic polymorphisms

Study Design

Primary Purpose

Basic / Translational

Classification

N/A: Not Applicable

Time Perspective

Retrospective

Masking

N/A: Not Applicable

Intervention Model

N/A: Not Applicable

Allocation

N/A: Not Applicable

Observational Study Model

Cohort

Eligibility and IRB

Gender

Both

Age Limits

Min:

Max:

IRB Approval

Yes

Healthy Volunteer

Study Description

We performed 2 case-control association studies whereby we looked at the role of genetic polymorphisms in ACE, eNOS and beta2-adrenergic receptors with risk of hypertension. We used historic controls who were previously recruited for a separate study (see the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation).

Manuscript 1: Akra-Ismail M, Makki RF, Chmaisse HN, Kazma A, Zgheib NK. Association between angiotensin-converting enzyme insertion/deletion genetic polymorphism and hypertension in a sample of Lebanese patients. Genet Test Mol Biomarkers. 2010 Dec;14(6):787-92 (PMID: 20939740 ).

Manuscript 2: Soudani NY, Fakhoury RM, Kaissi SS, Zgheib NK. The role of genetic polymorphisms in endothelial nitric oxide synthase and beta2-adrenergic receptors with risk of hypertension in a sample of Lebanese people. Saudi Med J. 2014 Mar;35(3):255-60 (PMID: 24623205).

Population Description

See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.

Sampling Method

See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.

Inclusion Criteria

See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.

Exclusion Criteria

See the role of CYP2C9 and VKORC1 genetic polymorphisms on anticoagulation study.

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