Clinical Research Details

Descriptive Information
Split-bolus contrast injection protocol triphasic computed tomography urography: utilization of contrast at reduced radiation dose

Fadi El-Merhi


Clinical Research - Development of New Technologies  

Conditions and Keywords
Renal urography,Computed tomography,Contrast delivery,Effective radiation dose
Study Design
N/A: Not Applicable
prospective and retrospective
N/A: Not Applicable
N/A: Not Applicable
N/A: Not Applicable
N/A: Not Applicable
Eligibility and IRB

The aim of this article was to investigate the opacification of the renal vasculature and the urogenital system during computed tomography urography by using a quadruple-phase contrast media in a triphasic scan protocol. 

Selected patients were referred from the Urology, nephrology, and emergency departments with a history of hematuria between July 2009 and September 2015.    

A total of 200 patients with possible urinary tract abnormalities were equally divided between 2 protocols. Protocol A used the conventional single bolus and quadruple-phase scan protocol (pre, arterial, venous, and delayed), retrospectively. Protocol B included a quadruple-phase contrast media injection with a triphasic scan protocol (pre, arterial and combined venous, and delayed), prospectively. Each pro- tocol used 100 mL contrast and saline at a flow rate of 4.5 mL. Attenuation profiles and contrast-to-noise ratio of the renal arteries, veins, and urogen- ital tract were measured. Effective radiation dose calculation, data analysis by independent sample t test, receiver operating characteristic, and visual grading characteristic analyses were performed. 

200 patients with possible urinary tract abnormalities 

Exclusion criteria were set for pregnant patients and patients with serum creatinine > 1.2 mg/dL or Estimated Glomerular filtration rate < 60 mL/min/1.73m2