Clinical Research Details

Descriptive Information
Significance of clostridium difficile in community-acquired diarrhea in a tertiary care center in Beirut, Lebanon

Mazen El Sayed
melsayed@aub.edu.lb

ER.ME.14
Completed- Has Results

Observational  


No
Collaborators
  • Abdul Rahman Bizri
Coordinators
Rana Bachir
rb52@aub.edu.lb
Conditions and Keywords
Diarrhea or abdominal symptoms
Clostridium difficile, Diarrhea
Study Design
Basic / Translational
N/A: Not Applicable
Retrospective
N/A: Not Applicable
N/A: Not Applicable
N/A: Not Applicable
Case-Only
Eligibility and IRB
Both
Min: 2
Max:
Yes
No

This retrospective study was conducted in the ED at the American University of Beirut Medical Center (AUBMC). AUBMC is the largest academic tertiary care medical center in Lebanon, and a major referral center for Lebanon and the region.
A chart review was done on adult patients ≥18 years of age who presented to the ED with the chief complaint of diarrhea and had a positive CDI during a three-year period (December 1, 2012 to December 1, 2015).

Variables collected included: demographics, history of exposure to individuals with CDI, prior history of CDI, antibiotic use within the past 3 months, type of antibiotic (if applicable), prior history of hospitalization and surgeries, other contributing factors (co-morbidities, intake of proton pump inhibitors (PPIs), laboratory studies and imaging, disposition and recurrence within 3 months).

The aim of our study is to describe C. difficile infections among patients presenting with diarrhea to the
Emergency Department (ED) of a tertiary care center in Beirut Lebanon, and to identify patients’ characteristics and clinical findings associated with this illness.

A chart review was done on adult patients ≥18 years of age who presented to the ED with the chief complaint of diarrhea and had a positive CDI during a three-year period (December 1, 2012 to December 1, 2015).
The diagnosis of CDI was in accordance with the Clinical Practice Guidelines set forth by Infectious Diseases Society of America (IDSA), whereby stool laboratory testing for toxins A and B was done as a confirmatory test after a positive Glutamate Dehydrogenase (GDH).

A retrospective study will be carried out on all charts of patients, who presented to the emergency department at AUBMC with the chief complaint of diarrhea or abdominal symptoms, and who had a positive C. diff infection by lab tests, during a three-year period spanning from December 1, 2012 and December 1, 2015. A chart review will also be done on all patients who were admitted to AUBMC, and who had diarrhea/abdominal symptoms and positive C. diff infection by lab tests within 48 hours of admission to the hospital over the same three year period.



··         All patients older than 2 years, who had positive C. diff lab tests, and acquired C. diff outside the hospital, will be included in the study

·         All patients who presented to the ED with Diarrhea/Abdominal symptoms during the study period (December 1, 2012 and December 1, 2015) and had positive C. diff infection by lab tests.

For this group of patients, community acquired C. diff is defined as the onset of symptoms occurring while the patient was outside a healthcare facility and the patient had not been discharged from a healthcare facility within 12 weeks before symptom onset.

·         All patients admitted to AUBMC during the study period (December 1, 2012 and December 1, 2015), who had Diarrhea/Abdominal symptoms, and had positive C. diff infection by lab tests within 48 hours of admission.

For this group of patients, community acquired C. diff is defined the onset of symptoms occurring within 48 hours upon admission to a healthcare facility and the patient had no prior stay in a healthcare facility within the 12 weeks prior to symptom onset.


·         Children less than 2 years will be excluded because asymptomatic high carrier rates have been reported in children <2 years of age

·         Patients who acquired C. diff inside the hospital (48 hours after admission to the hospital)

·         Patients with missing charts will be excluded from the study.