Clinical Research Details

Descriptive Information
The Incidence and Risk Factors of Diverticular Disease in Patients with Incidental Diverticulosis: A Prospective Cohort Study

Ala Sharara

Completed- Has Results


  • Rani Shayto
Louma Rustam
Extension: 5909
Conditions and Keywords
diverticulosis,diverticulitis,colonic abscess,colonic perforation,screening colonoscopy
Study Design
N/A: Not Applicable
N/A: Not Applicable
Single Group
N/A: Single arm study
N/A: Not Applicable
Eligibility and IRB
Min: 18

This is a prospective cohort study aimed at determining the natural history of diverticulosis, diverticular disease manifestation incidence, and diverticular disease risk factors in previously asymptomatic patients following screening colonoscopy.

  1. Defining the incidence of diverticular disease among Lebanese patients who were incidentally found to have diverticulosis on screening colonoscopy (primary objective)
  2. Assessing the different diverticular manifestations and risk factors predisposing to disease incidence (secondary objective)
  3. Assessing recurrence rate (secondary objective)

Data will be collected from all patients who had underwent screening colonoscopy at the American University of Beirut Medical Center Endoscopy Unit beginning from 2005 and who have been found to have incidental diverticulosis.

Patients who had underwent screening colonoscopies and found to have incidental diverticulosis since 2005 will be consented and enrolled in the study. Data collection and chart reviews will take place, and patient health status will be prospectively followed up until 2015. Patients will be contacted and consented over the phone, and interval history of diverticular complications will be recorded as reported by patients through direct phone contact and through chart reviews of admissions or outpatient clinic visits directly pertaining to diverticular disease complications.

  1. Age 18 or older
  2. Presence of colonic diverticula on screening colonoscopy

  1. Age below 18 
  2. Refusal to consent to the study
  3. Patients in whom a complete colonoscopy was unable to be performed
  4. Lower gastrointestinal bleed due to other causes (hemorrhoids, angiodysplasia etc)
  5. Colorectal cancer
  6. Inflammatory Bowel disease
  7. Infectious colitis
  8. Patients who underwent partial or total colectomy
  9. Prior history of diverticulitis or diverticular bleeding