Clinical Research Details

Descriptive Information
Risk Factors for Nosocomial Clostridium Difficile Infection (CDI) at a Tertiary Care Center: A Prospective Study

Ala Sharara

Completed- Has Results


  • Souha Kanj
  • Ghassan Matar
  • George Araj
  • Rami Mahfouz
  • Rani Shayto
  • Astellas Pharma
Louma Rustam
Extension: 5909
Conditions and Keywords
clostridium difficile infection
clostridium difficile ,C. Diff,CDI,risk factors,Tertiary care center
Study Design
N/A: Not Applicable
N/A: Not Applicable
Single Group
N/A: Single arm study
N/A: Not Applicable
Eligibility and IRB
Min: 18

This is a prospective observational study conducted at the American University of Beirut Medical Center aiming at:

1. Determining the risk factors of nosocomial clostridium difficile infection (CDI) (primary objective)

2. Determining the ribotype of Clostridium Difficile responsible for nosocomial and relapsing CDI in the American University of Beirut Medical Center (primary ojbective)

3. Determining the relapse rate of CDI within 8 weeks of hospital discharge defined as either repeat hospitalization or outpatient CDI relapse documentation by repeat stool testing (secondary objective)

200 prospective patients will be consecutively recruited following diagnosis of Clostridium Difficile by Toxin A/B or PCR.

Following diagnosis of Clostridium Difficile, patients will be consented to enroll in the study and their medical records checked for relevant study information. Stool samples will also undergo Clostridium Difficile ribotyping. Patients will be enrolled consecutively until 200 samples are reached.

  1. Age 18 or older
  2. Confirmed diagnosis of Clostridium Difficile by Toxin / PCR 
  3. Willing to consent   

  1. Age less than 18
  2. Not willing to consent
  3. Not diagnosed with Clostridium Difficile infection