Clinical Research Details

Descriptive Information
Epidemiology, Risk Factors and Outcomes of Meningioma Patients

Hazem Assi


Clinical Research - Epidemiologic and Behavioral Studies  

Mohamad Srour
Extension: 7902
Conditions and Keywords
Meningioma Patients
Epidemiology,Outcomes,Demographics,Risk factors
Study Design
N/A: Not Applicable
N/A: Not Applicable
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N/A: Not Applicable
Eligibility and IRB

Meningioma is a tumor arising from the meningeal cells covering the brain and spinal cord. It is reported to be the most frequently diagnosed intracranial primary brain tumor accounting for about 30% of all primary brain and Central nervous system (CNS) tumors. The disease pathology varies widely between low grade, which is typically a benign disease, high grade with more aggressive behaves as a malignant disease, and intermediate grade that behaves in between. Regardless of grade, meningioma still cause a burden on patients and health care systems because of the critical location they grow at, causing significant morbidity and even mortality in some cases.

Multiple risk factors have been reported to be associated with meningioma, with varying degree of evidence supporting each of them. Moreover, several epidemiologic studies have been reported to compare occupational, ethnic, or racial variation in incidence of meningiomas. No study reporting the incidence and epidemiological data of meningioma in the Middle East has been reported in the literature. Hence our project is the first to attempt to study the epidemiology of meningioma in patients treated at the American University of Beirut Medical Center (AUBMC), and to compare it with that of the world literature in order to evaluate for risk factors associated with the different types of meningioma among the population and compare it to known factors in literature. ,To determine prognostic factors in the different types of meningioma with an emphasis on patient characteristics, tumor characteristics as well as management approaches  and finaly To analyze any difference in outcome between patients with the different types of meningioma.

Given the rare incidence of the disease, list of the meningioma patient names will be obtained form AUBMC tumor registry. Chart review of all the cases will be done at AUBMC medical records, AUB radiation oncology department, and AUB neurosurgery department.

All patients with either radiological or pathological diagnosis of meningioma between January 1st 2005 and December 18th 2015 inclusive will be identified from AUBMC databases.

This study will be a single institution retrospective cohort study based on chart review of all cases of meningioma seen at the American University of Beirut Medical Center (AUBMC), over a period of 10 years (January 1st of 2005 until December 18th 2015). A list with the names of these patients will be obtained from the institutional tumor registry at AUBMC.

We aim to determine the overall survival and disease-free survival in various subgroups and compare them for any significant differences. This data will be obtained from medical charts if available. If outcomes data is not available, the patient’s primary attending will be calling patients if still alive or a family member to get an oral consent. Oral consent is essential, knowing that additional information about the patient is most likely to be sought from family members.

Eligible patients include patients with a histologically or radiologically proven meningioma. All age groups included. Between January 2005 – December 2015 inclusive